![]() 2020) and modulation of neurotransmitters (e.g., release of intracellular gamma-aminobutyric acid (GABA) or facilitation of descending inhibition involving serotoninergic mechanisms (Janssen et al. SCS has been shown to act via numerous physiological processes including regulation of neuroinflammatory responses (e.g., glial activation (Vallejo et al. Spinal cord stimulation (SCS) is used as a safe and effective option for multiple chronic neuropathic pain disorders (Kumar et al. This approach may offer a better method for translating SCS parameters between species that will improve understanding of the mechanisms of SCS action to further advance future clinical applications. The use of ECAP-based SCS dose implemented in ECAP-controlled CL-SCS produced analgesia in animals subjected to an experimental model of neuropathic pain. An analysis of conduction velocities of the evoked signals confirmed the involvement of large, myelinated fibers. Importantly, the use of ECAP-based SCS dose, implemented in ECAP-controlled CL-SCS, significantly reduced mechanical and cold hypersensitivity in SNI SCS-ON animals through the constant and controlled activation of dorsal column fibers. The recorded ECAPs showed the characteristic triphasic morphology and the ECAP amplitude (mV) increased as higher currents (mA) were applied in both SNI animals and controls (SNI SCS-ON and sham SCS-ON). Comparisons between SNI rats and their controls as well as between stimulation parameters were made using omnibus analysis of variance (ANOVA) tests and t-tests. The responses of dorsal column fibers to SCS were characterized and sensitivity towards mechanical and cold stimuli were assessed to determine analgesic effects from ECAP-controlled CL-SCS. A specially designed multi-channel system was used to record ECAPs and to apply ECAP-controlled CL-SCS for 30 min at 50 Hz 200 µs. A custom-made six-contact lead was implanted epidurally covering T11-元, as confirmed by computed tomography or X-ray. MethodsĪdult male Sprague–Dawley rats (200–300 g) were subjected to spared nerve injury (SNI). This study assessed, for the first time, the feasibility of recording ECAPs and applying ECAP-controlled CL-SCS in freely behaving rats subjected to an experimental model of neuropathic pain. Therefore, ECAPs may provide an objective surrogate for SCS dose in preclinical models that may support better understanding of SCS mechanisms and further translations to the clinics. This measure approximates the onset of SCS-induced sensations in humans and provides effective analgesia when used with ECAP-controlled closed-loop (CL)-SCS systems. The evoked compound action potential (ECAP) represents a measure of dorsal column fiber activation. Preclinical models of spinal cord stimulation (SCS) are lacking objective measurements to inform translationally applicable SCS parameters.
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